"Synthesis of some indole nitriles"

Author: Nino Zviadadze
Keywords: indole, 3-cyanomethyl-2-ethoxycarbonylinidol, 3, 3'-bis-aminomethyl-2, 2'-diethoxy-carbonyl-bis-(indole-5-yl)oxide
Annotation:

The new nitriles and binitriles: 3-cyanomethyl-2-ethoxycarbonylindole and 3,3’-biscyanomethyl-2,2’-diethoxycarbonyl-bis(indole-5-yl)-oxyde have been prepared by using indole and ethoxycarbonyl derivatives of bis-(indole-5-yl)oxide. Prepare for the new mono- and bi- analoges of gramine we used Mannich reaction – aminomethylation of indole and ethoxycarbonyl derivatives of bis-(indole-5-yl)oxide by using diethylamine, formaldehyde and acetic acid. Shown, that obtained the derivatives of cyanomethyles by transformation of this compounds is possible. The structure of synthesized compounds was established by NMR, IR and mass-spectroscopy.