Separation of Enantiomers of some chiral Sulfoxides by High Performance Liquid Chromatography using Metanol and Acetonitrile as mobile phases

Author: Elene Gvazava
Keywords: new chiral sulfoxides, eluation order, polysaccharide-based chiral selectors, Methanol
Annotation:

The aim of the study was to separate enantiomers of new chiral sulfoxides and to compare the eluation order of enantiomers using some polysaccharide-based chiral selectors in high-performance liquid chromatography (HPLC). 13 new chiral sulfoxides were studied. Methanol and acetonitrile were used as mobile phases. Based on this study it was established that chemical structure of an analyte and structure of chiral selector have the influence on enantioselectivity. The highest number of successful enantioseparations was achieved on cellulose tris(4-chloro-3-methylphenylcarbamate)-based chiral column. The highest number of the enantiomer elution order reversal was observed between the above mentioned column and the column based on amylose tris(3,5-dimethylphenylcarbamate).

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