Separation of Enantiomers of some chiral Sulfoxides by High Performance Liquid Chromatography by using Hexane-Ethanol type mobile phases

Author: Tiniko Elbakidze
Keywords: Chiral sulfoxides, high-performance liquid chromatography
Annotation:

The aim of the project is the study of enantioseparation of chiral sulfoxides in High Performance Liquid Chromatography. Study of enantioselectivity is now a top-class subject for academic research and in modern pharmaceutical industry, as about more than 50 % of the drugs currently in use are chiral compounds and important part of them are racemates consisting of an equimolar mixture of two enantiomers, stereoisomers with different biological activities. In many cases, one enantiomer is the active pharmaceutical ingredient while the other inactive enantiomer shows unwanted side effects or even toxic effects. The goal of the present study was to investigate structure-enantioselectivity relationship for some newly synthesized chiral sulfoxides on polysaccharide-based chiral selectors in high-performance liquid chromatography. For this purpose together with new chiral sulfoxides also 16 non-commercial cellulose-phenylcarbamate-based chiral selectors were synthesized. Based on these studies some conclusions can be made on the mechanism of enantiomer separation and the process can be further optimized.

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