Synthesis derivatives of p-tolyl-N-β-D-galactopyranosylamines

A n n o t a t I o n Natia Kiladze Synthesis derivatives of p-tolyl-N-β-D-galactopyranosylamines Department of Chemistry, Iv.Javakhishvili Tbilisi State University, Ilia Chavchavadze Ave. 3 Modification of carbohydrates by various types of organic compounds has recently played a significant role in the synthesis of new of biological snd pharmacologically active compounds. Little has been published about carbohydrates containing nitrozo group. The application of glycosides for the modification of biologically active organic compounds, on the one hand, change their biological and physiological action, and on the other, may reduce their toxicity. The goal of present investigation consist in synthesis of N-galactosylamines containing in a molecule nitrosogroup (N=O). Аs аn initial substance in the given work has been used the products of condensation of D-galactose (1) from p-toluydines  N-p-tolyl-β–D–galactopyranozylamine (2), whose acetylated in the pyridine area synthesized N-β-(p-tolyl) -2,3,4,6-tetra-0-acetyl-D-galactopyranosylamine (3) according to the following scheme: The structures of obtained compounds were established by physical-chemical methods of analysis.