Synthesis of Aryl-N-glycosides Derivatives

Author: ketevani onashvili
Keywords: glicoside, glucose, mannose, IR spectroscopy, UV spectroscopy
Annotation:

Modification of carbohydrates by various types of organic compounds has recently played a significant role in the synthesis of new of biological snd pharmacologically active compounds. Little has been published about carbohydrates containing nitrozo group. The application of glycosides for the modification of biologically active organic compounds, on the one hand, change their biological and physiological action, and on the other, may reduce their toxicity. The goal of present investigation consist in synthesis of N-glycosilamines containing in a molecule nitrosogroup (N=O). Аs аn initial substance in the given work has been used the products of condensation of D-glucose (1) and D-mannose (2) from p-aminobenzoic acid ethyl ester N-p-aminobenzoic acid ethyl ester-β–D–mannopyranozylamine and N-p- aminobenzoic acid ethyl ester -β–D–glucopyranozylamine (3,4). By interaction of compounds (3, 4) with sodium nitrite corresponding nitrosoderivatives (5,6) has been received. The structures of obtained compounds were established by physical-chemical methods of analysis

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