The separation of multiresistant Enterococcus and the determination of it's mechanism of action

Enterococcus is a bacteria,which commonly lives in a human’s gastrointestinal tract and female urogenital system,without causing any pathological changes or infection, thus it is considered as a human’s normal flora,so human is carrier of it. Enterococcus can cause infection in case if it gets into blood,urine or wound. The bacteria do not normally cause infections in healthly ones,but can cause in people with low immune system,for example people undergoing organ transplant, renal dialysis, cancer treatment. The antibiotic vancomycin is used for treatment of serious enterococci infection,but nowadays enterococcus is resistant againt vancomycin. First study about vancomycin resistant bacteries was published in 1986. After this about this matter the interest was increased towards phageothrapy. The positive effect of bacteriophage is it’s specifity and harmlessness. The aim of work was the separation of active bacteriophages against antibiotic-resistant enterococuss,reproduction and study the mechanism of it’s action. As a result of a research from the flowing down water was separated Enterococcus 104 with capacity 7.5x104. . After the adaptation and concentration it’s capacity was 3.6x109 . Whereas the activity with Apelman method was 106. So we studied the range of phage Enterococcus 104 to Enterococcus 1, Enterococcus 2, Streptococcus 1, streptococcus 2, Staphylococcus, Escherichia Coli, Pseudomona strains and was confirmed that the phage Enterococcus 104 is specific and doesn’t act with other varieties of strains.