Seporation of terbutalins enantiomers with capillary electrophoresis and structural research of selector and selectant.

Author: giorgi farulava
Keywords: Cyclodextrine, capillary Electrophoresis, Enantiomers, Terbutaline, Migration row, Nuclear magnetic resonance, Racemate
Annotation:

Chiral forms of enantiomeric chemicals often differ in their biological reactivity, creation of chiral chemicals in their pure forms is important not only for chemistry but for other fields as well. The main method of separating enantiomers is capillary electrophoresis, this method is highly effective and using this method saves chemicals and is highly cost efficient, it is ecologically safe. In this work cyclodextrines were used as chiral selectors, and we studied their interaction with terbutalin and its enantiomers, as well as its impact on migration row within kapilary electrophoresis. Using nuclear magnetic resonance method and molecular modeling, we studied the structure of selector/selectant in which the migration row was changed within capillary electrophoresis.

Lecture files:

გიორგი ფარულავა, საბაკალავრო პრეზენტაცია. [ka]
გიორგი-ფარულავა-საბაკალავრო-ნაშრომი. [ka]